STIOLTO/INSPIOLTO (Tiotropium/ Olodaterol)

What is this medication?

Tiotropium+Olodaterol, Stiolto Respimat/Inspiolto Respimat
Anticholinergic, Beta agonist, long- acting, inhalant (oral)

Brand Name US: Stiolto
Canadian Equivalent: Inspiolto 

Indicated for treatment of chronic obstructive pulmonary disease (COPD).

How does this medication work?

Tiotropium is an anticholinergic agent that is a reversible competitive inhibitor of type 3 muscarinic (M3) receptors which causes the smooth muscle in the bronchi to relax and subsequently leads to bronchodilation.

Olodaterol is a selective beta agonist that binds to beta2 receptors located on the bronchial smooth muscle causing the airway to dilate reducing the work required to breath while having little effect on heart rate.

What should I watch for while using this medication?

Before starting Tiotropium+Olodaterol, Stiolto Respimat/Inspiolto Respimat make sure your physician is aware of any allergies or medications you currently take.  Hyperthyroidism, cardiovascular disease, electrolyte disturbances, urinary retention and rare paradoxical cases of life-threatening bronchospasm have been reported.

How should I take this medication?

Oral Inhalation: Soft Mist Inhaler

Take two inhalations once daily (maximum: 2 inhalations per day.)

How to Take: Administer at the same time each day. Prime inhaler prior to initial use or if not used for >21 days by pointing inhaler towards ground and actuating until aerosol cloud is seen, then repeat 3 additional times before use.  If not used for >3 days (but ≤21 days), actuate once before use. To prepare inhaler for use after priming, refer to manufacturer labeling.  When dose is ready to be administered, breathe in slowly through the mouth and press the dose release button; continue to breathe in slowly as long as possible, then hold breath for 10 seconds or for as long as comfortable. Repeat for second inhalation.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose. Do not take more than one dose (two puffs) per day.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 15 to 30° C protected from light, heat, and moisture. Do not freeze.

What are the possible side effects of using this medication?

Nasopharyngitis, cough, muscle, and joint pain

Note this is not a complete list of side effects, only common ones.