QULIPTA (Atogepant)

What is this medication?

Qulipta (atogepant) belongs to a class of medications called calcitonin gene-related peptide receptor (CGRP) antagonists. CGRP is a protein found in the brain and nervous system that is thought to contribute to the pain, inflammation, and vasodilation associated with migraine attacks.

Qulipta is a prescription medicine used in adults to help prevent migraine headache (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound or light).

Qulipta works by blocking the action of the CGRP protein in the body. This helps prevent migraine headaches.

How should I use this medication?

Take Qulipta exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

You may take Qulipta with or without food.

Dosing information:

Usual Adult Dose for Migraine Prophylaxis:

10 mg, 30 mg, or 60 mg orally once a day .

Use: For the preventative treatment of episodic migraine.

What if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

How should I store this medication?

Store at room temperature away from moisture and heat.

What are the possible side effects of using this medication?

Get emergency medical help if you have signs of an allergic reaction to Qulipta:

• hives;
• difficulty breathing;
• swelling of your face, lips, tongue, or throat.

Common Qulipta side effects may include:

• nausea, constipation;
• feeling tired; or
• weight loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Qulipta?

Tell your doctor about all your current medicines. Many drugs can affect atogepant, especially:

• cyclosporine;
• St. John's wort;
• an antibiotic such as clarithromycin or rifampin;
• antifungal medicine such as itraconazole or ketoconazole;
• antiviral medicine to treat HIV, such as efavirenz or etravirine; or
• seizure medicine such as carbamazepine or phenytoin.

This list is not complete and many other drugs may affect atogepant. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.