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LUMAKRAS (Sotorasib)

LUMAKRAS (Sotorasib)

Regular price $13,518.00 USD
Regular price Sale price $13,518.00 USD
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What is this medication?

Lumakras is a prescription medicine used to treat adults with non-small cell lung cancer (NSCLC):

that has spread to other parts of the body or cannot be removed by surgery, and whose tumor has an abnormal KRAS G12C gene, and who have received at least one prior treatment for their cancer.

Your healthcare provider will perform a test to make sure that Lumakras is right for you.

It is not known if this medicine is safe and effective in children.

What are the ingredients in Lumakras?

Active Ingredient: sotorasib

Inactive Ingredients: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, and magnesium  stearate. Tablet film coating material contains polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and iron oxide yellow.

How should I use this medication?

Take Lumakras exactly as your healthcare provider tells you to take it. Do not change your dose or stop taking Lumakras unless your healthcare provider tells you to.

Take Lumakras tablets 1 time each day, at about the same time each day.

Take the tablets with or without food.

Swallow the tablets whole. Do not chew, crush, or split tablets.

If you cannot swallow the tablets whole:

Place your daily dose in a glass of 4 ounces (120 mL) of non-carbonated, room temperature water without crushing the tablets. Do not use any other liquids.

Stir until the tablets are in small pieces (the tablets will not completely dissolve). The color of the mixture may be pale yellow to bright yellow.

Drink the tablet and water mixture right away or within 2 hours of preparing. Do not chew pieces of the tablet.

Rinse the glass with an additional 4 ounces (120 mL) of water and drink to make sure that you have taken the full dose.

If you do not drink the mixture right away, stir the mixture again before drinking.

If you take an antacid medicine, take Lumakras either 4 hours before or 10 hours after the antacid.

If you vomit after taking a dose, do not take an extra dose. Take your next dose at your regularly scheduled time the next day.

What if I miss a dose?

If you miss a dose of Lumakras, take the dose as soon as you remember. If it has been more than 6 hours, do not take the dose. Take your next dose at your regularly scheduled time the next day. Do not take 2 doses at the same time to make up for a missed dose.

Get your prescription refilled before you run out of medicine completely.

How should I store this medication?

Store Lumakras at room temperature between 68°F to 77°F (20°C to 25°C).

The bottle has a child-resistant closure.

Keep all medicines out of the reach of children and pets.

What are the possible side effects of using this medication?

Lumakras may cause serious side effects, including:

Liver problems. Lumakras may cause abnormal liver blood test results. Your healthcare provider should do blood tests before starting, and during treatment to check your liver function. Tell your healthcare provider right way if you get any signs or symptoms of liver problems, including:

  • your skin or the white part of your eyes turns yellow (jaundice)
  • dark or "tea-colored" urine
  • light-colored stools (bowel movements)
  • tiredness or weakness
  • nausea or vomiting
  • bleeding or bruising
  • loss of appetite
  • pain, aching, or tenderness on the right side of your stomach-area (abdomen)
  • Lung or breathing problems. Lumakras may cause inflammation of the lungs that can lead to death. Tell your healthcare provider or get emergency medical help right away if you have new or worsening shortness of breath, cough or fever.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment if you develop side effects. The most common side effects include:

  • diarrhea
  • muscle or bone pain
  • nausea
  • tiredness
  • liver problems
  • cough
  • changes in liver function tests
  • changes in certain other blood tests

These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Amgen at 1-800-772-6436 (1-800-77-AMGEN).

Lumakras side effects (more detail)

What other drugs will affect Lumakras?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with sotorasib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

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