COMBIGAN (Brimonidine/Timolol)

What is this medication?

COMBIGAN (Brimonidine/Timolol)
Ophthalmic Alpha2 Agonist; Ophthalmic Beta Blocker

COMBIGAN, the combination of Brimonidine and Timolol (Ophthalmic), is officially indicated to treat elevated intraocular pressure secondary to open angle glaucoma or ocular hypertension who require adjunct or replacement therapy due to uncontrolled intraocular pressure.

How does this medication work?

Brimonidine reduces aqueous humor production and increases uveoscleral outflow via selective alpha2 agonism thereby reducing intraocular pressure.  

Timolol reduces intraocular pressure by reducing aqueous humor production and possibly increasing its outflow via blocking both beta1– and beta2-adrenergic receptors. 

How should I take this medication?

Ophthalmic: Instill one drop into affected eye(s) twice daily approximately every 12 hours.

Note: Remove contact lenses before applying and wait at least 15 minutes after administration before reinserting.  

How to Take: Follow instructions provided by physician/pharmacy label, use consistently at same times each day unless otherwise directed, store at room temperature.  Apply light pressure to lacrimal sac (inside corner of eye near nose) for 60 seconds after application to prevent drainage of the drop from eye.

What should I watch for while using this medication?

Before starting COMBIGAN (Brimonidine/Timolol), make sure your physician is aware of any allergies or medications you currently take (MAO inhibitors), if you have a history of bronchial asthma, severe chronic obstructive pulmonary disorder, cardiovascular disease, diabetes, myasthenia gravis, cerebrovascular disease, a thyroid disorder, if you are pregnant, or breastfeeding.

What if I miss a dose?

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use two doses at one time.

How should I store this medication?

Keep out of the reach of children at all times. Store at cool room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Do not freeze.

What are the possible side effects of using this medication?

Drowsiness (children), allergic conjunctivitis, burning sensation or stinging of the eyes, hyperemia (bloodshot eyes), and pruritis are the most common side effects.

Note this is not a complete list of side effects for COMBIGAN (Brimonidine/Timolol), only common ones.